Problem Addressed

Diarrhea is a leading cause of illness and death in children worldwide, particularly in malnourished populations.
What We Did

Our research demonstrated the effectiveness of zinc combined with oral rehydration salts (ORS) in treating diarrhea in children.
What We Found

Zinc significantly reduced the duration and severity of diarrhea and lowered the risk of persistent diarrhea.
Impact

Our findings, along with those from other research groups, informed national health protocols, making zinc supplementation a widely adopted strategy in managing diarrhea globally.
Real-World Impact

Zinc supplementation has become a lifesaving intervention, preventing thousands of deaths annually in resource-limited settings.
Investigators

Nita Bhandari, Sunita Taneja, Sarmila Mazumder, MK Bhan
- Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children. Pediatrics 2002 Jun;109(6):e86. DOI: 10.1542/peds.109.6.e86.
- Effect of routine zinc supplementation on pneumonia in children 6 months to 3 years: a randomized controlled trial in an urban slum. BMJ 2002 Jun 8;324(7350):1358. DOI: 10.1136/bmj.324.7350.1358
- A Pilot Test of the Addition of Zinc to the Current Case Management Package of Diarrhea in a Primary Healthcare Setting. J Pediatr Gastroenterol Nutr 2005; 41(5):685-687. DOI: 10.1097/01.mpg.0000182799.69675.92.
- Effectiveness of zinc supplementation plus oral rehydration salts compared with oral rehydration salts alone as a treatment for acute diarrhea in a primary care setting: a cluster randomized trial. Pediatrics. 2008 May;121(5):e1279-85. DOI: 10.1542/peds.2007-1939.
- Effectiveness of zinc supplementation plus oral rehydration salts for diarrhoea in infants aged less than 6 months in Haryana state, India. Bull World Health Organ. 2010 Oct 1;88(10):754-60.DOI: 10.2471/BLT.10.075986.


