High Quality Scientific Evidence to Inform Policies and Programs

Our groundbreaking research has informed global and national health policies, improved healthcare delivery, and saved countless lives. These landmark studies highlight our commitment to solving critical health challenges through innovation, collaboration and evidence-based solutions.

Zinc for Acute Diarrhea
Exclusive Breastfeeding for Six Months
WHO 2006 Growth Standards
Integrated Management 
of Neonatal and Childhood Illness (IMNCI)
Clinical Development of a Rotavirus Vaccine
Neonatal Vitamin A Supplementation
Rehabilitation of Children with Severe Acute Malnutrition (SAM)
Kangaroo Mother Care (KMC) Initiated in the Community
Women and Infant Integrated Interventions for Growth Study (WINGS)
Guidelines for the Care
 of Preterm or Low Birthweight Infants

Problem Addressed

Diarrhea is a leading cause of illness and death in children worldwide, particularly in malnourished populations.

What We Did

Our research demonstrated the effectiveness of zinc combined with oral rehydration salts (ORS) in treating diarrhea in children.

What We Found

Zinc significantly reduced the duration and severity of diarrhea and lowered the risk of persistent diarrhea.

Impact

Our findings, along with those from other research groups, informed national health protocols, making zinc supplementation a widely adopted strategy in managing diarrhea globally.

Real-World Impact

Zinc supplementation has become a lifesaving intervention, preventing thousands of deaths annually in resource-limited settings.

Investigators

Nita Bhandari, Sunita Taneja, Sarmila Mazumder, MK Bhan

Read More
  • Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children. Pediatrics 2002 Jun;109(6):e86. DOI: 10.1542/peds.109.6.e86.
  • Effect of routine zinc supplementation on pneumonia in children 6 months to 3 years: a randomized controlled trial in an urban slum. BMJ 2002 Jun 8;324(7350):1358. DOI: 10.1136/bmj.324.7350.1358
  • A Pilot Test of the Addition of Zinc to the Current Case Management Package of Diarrhea in a Primary Healthcare Setting. J Pediatr Gastroenterol Nutr 2005; 41(5):685-687. DOI: 10.1097/01.mpg.0000182799.69675.92.
  • Effectiveness of zinc supplementation plus oral rehydration salts compared with oral rehydration salts alone as a treatment for acute diarrhea in a primary care setting: a cluster randomized trial. Pediatrics. 2008 May;121(5):e1279-85. DOI: 10.1542/peds.2007-1939.
  • Effectiveness of zinc supplementation plus oral rehydration salts for diarrhoea in infants aged less than 6 months in Haryana state, India. Bull World Health Organ. 2010 Oct 1;88(10):754-60.DOI:  10.2471/BLT.10.075986.

Problem Addressed

Suboptimal breastfeeding practices contribute to high rates of infant illness and malnutrition.

What We Did

We introduced an educational intervention in mothers to promote exclusive breastfeeding  in infants up to six months in rural Haryana.

What We Found

Exclusive breastfeeding rates were significantly higher in communities where health workers counseled mothers, reducing diarrhea prevalence and supporting healthy infant growth.

Impact

Our research contributed to data that led to the WHO and national recommendations for extending the duration of exclusive breastfeeding from infant age 4 months to 6 months.

Real-World Impact

Our study, along with those by other groups, paved the way for extension of the duration of maternity leave to 6 months and a ban on advertisement of commercial infant formula till 6 months.

Investigators

Nita Bhandari, Sarmila Mazumder, MK Bhan

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  • Effect of community based promotion of exclusive breast feeding on diarrheal illnesses and growth: a cluster randomised controlled trial. Lancet. 2003 Apr 26;361(9367):1418-23. DOI: 10.1016/S0140-6736(03)13134-0.

Problem Addressed

Existing growth charts did not accurately reflect growth patterns of healthy children.

What We Did

The investigators at SAS were a part of the WHO-led study to develop global growth standards based on children from six countries, including India.

What We Found

Our data showed that the growth of Indian children residing in settings free from environmental constraints is similar 
to that of children in developed countries.

Impact

These growth standards are now used worldwide, including in India’s child monitoring programs.

Real-World Impact

The standards ensure accurate tracking of child growth and nutrition, enabling relevant interventions for undernutrition and stunting.

Investigators

Nita Bhandari,Sunita Taneja, Temsunaro Rongsen Chandola, Pooja Sharma, MK Bhan.

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Problem Addressed

High neonatal and infant mortality rates occur due to limited newborn care in home settings.

What We Did

We evaluated the IMNCI program, which combines improved treatment for childhood illnesses with home visits for newborn care.

What We Found

IMNCI reduced infant deaths by 15% and improved newborn care practices.

Impact

The program is a model for improving child survival in resource-limited settings.

Real-World Impact

IMNCI has been adopted in India, saving lives and improving care for newborns in vulnerable communities.

Investigators

Nita Bhandari,
Sarmila Mazumder, Sunita Taneja.

Read More
  • Effect of implementation of Integrated Management of Neonatal and Childhood Illness (IMNCI) programme on neonatal and infant mortality: cluster randomised controlled trial. BMJ. 2012 Mar 21;344:e1634 . DOI: 10.1136/bmj.e1634.
  • Effect of implementation of integrated management of neonatal and childhood illness programme on treatment seeking practices for morbidities in infants: cluster randomised trial. BMJ. 2014 Aug 29;349:g4988. DOI: 10.1136/bmj.g4988.

Problem Addressed

Rotavirus is a major cause of severe diarrhea in young children, often leading to death in low-resource settings.

What We Did

We were a part of the team that evaluated ROTAVAC®, India’s first indigenously manufactured rotavirus vaccine. We participated in all phases of the clinical trials conducted at the All India Institute of Medical Sciences (Phase I trial) and SAS (Phases II and III) across urban and rural India as well as the post-introduction evaluation (Phase IV).

What We Found

ROTAVAC® reduced severe diarrhea cases by over 50% and was a safe, affordable vaccine.

Impact

Introduced in the Universal Immunization Program of India, ROTAVAC® now protects millions of children.

Real-World Impact

The vaccine has significantly reduced childhood deaths from diarrhea, offering hope for low-resource settings globally.

Investigators

Nita Bhandari, Temsunaro Rongsen-Chandola, Sunita Taneja, Nidhi Goyal, 
Pooja Sharma

Read More
  • Safety and immunogenicity of two live attenuated human rotavirus vaccine candidates, 116E and I321, in infants: Results of a randomised controlled trial. Vaccine 2006; 24(31-32):5817-23. DOI: 10.1016/j.vaccine.2006.05.001.
  • A dose escalation safety and immunogenicity study of live attenuated oral rotavirus vaccine 116E in infants: a randomized, double blind, placebo controlled trial. J Infect Dis 2009; 200-421-9. DOI: 10.1086/600104.
  • Efficacy of a Monovalent Human-Bovine (116E) Rotavirus Vaccine in Indian Infants: A Randomised Double Blind Placebo Controlled Trial. Lancet. 2014 Jun 21;383(9935):2136-43. DOI: 10.1016/S0140-6736(13)62630-6.
  • Efficacy of monovalent human-bovine (116E) rotavirus vaccine in Indian children in the second year of life. Vaccine. 2014 Aug 11;32 Suppl 1:A110-6. DOI: 10.1016/j.vaccine.2014.04.079.
  • Assessment of risk of intussusception after pilot rollout of rotavirus vaccine in the Indian public health system. Vaccine. 2020;38(33):5241-5248. doi:10.1016/j.vaccine.2020.05.093

Problem Addressed

Vitamin A deficiency contributes to high infant mortality in developing countries.

What We Did

We assessed the impact of neonatal vitamin A supplementation within 72 hours of birth in a large trial.

What We Found

We found a modest reduction in mortality in the first 6 months of life.

Impact

Our findings informed WHO guidelines on vitamin A supplementation for regions where vitamin A deficiency is a moderate public health problem.

Real-World Impact

Neonatal vitamin A programs are helping reduce mortality in areas with high vitamin A deficiency.

Investigators

Nita Bhandari, Sarmila Mazumder, Sunita Taneja

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  • Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovita): a randomised, double-blind, placebo-controlled trial. Lancet. 2015 Apr 4;385(9975):1333-42. DOI: 10.1016/S0140-6736(14)60891-6.

Problem Addressed

SAM requires effective, scalable home-based treatments.

What We Did

We compared the effectiveness of different regimens for the rehabilitation of children with SAM.

What We Found

It is possible to treat children with SAM 
at home.

Impact

The findings led to rethinking about ways to combat the problem of SAM and implementation of district-based nutrition programs in several Indian states.

Real-World Impact

Home-based management of SAM is practiced widely and helps in saving lives.

Investigators

Nita Bhandari, 
Sunita Taneja, 
Sanjana Brahmawar Mohan, Sarmila Mazumder

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  • Efficacy of three feeding regimens for home-based management of children with uncomplicated severe acute malnutrition: a randomised trial in India. BMJ Glob Health. 2016 Dec 30;1(4):e000144. DOI: 10.1136/bmjgh-2016-000144.

Problem Addressed

Low-birthweight 
babies face high risks of mortality and illness.

What We Did

We conducted a community-based study to assess the impact of kangaroo mother care (skin-to-skin contact and breastfeeding).

What We Found

Babies receiving KMC were 30% less likely to die in the first 28 days and 25% less likely to die in the first 6 months.

Impact

WHO now recommends KMC as the standard of care for stable, low-birthweight babies.

Real-World Impact

KMC has become a global standard, helping low-birthweight babies thrive in resource-limited settings.

Investigators

Sarmila Mazumder, 
Arun Singh Jadaun, Sunita Taneja, Bireshwar Sinha, Ravi Prakash Upadhyay, Nita Bhandari

Read More
  • Kangaroo mother care: using formative research to design an acceptable community intervention. BMC Public Health. 2018 Mar 2;18(1):307.  DOI: 10.1186/s12889-018-5197-z.
  • Effect of community-initiated kangaroo mother care on survival of infants with low birthweight: a randomised controlled trial. Lancet. 2019 Nov 9;394(10210):1724-1736.DOI:10.1016/S0140-6736(19)32223-8.
  • Community initiated kangaroo mother care and early child development in low birth weight infants in India-a randomized controlled trial. BMC Pediatr. 2020;20(1):150. DOI: 10.1186/s12887-020-02046-4.
  • Effect of Community-Initiated Kangaroo Mother Care on Postpartum Depressive Symptoms and Stress Among Mothers of Low-Birth-Weight Infants: A Randomized Clinical Trial. JAMA Netw Open. 2021 Apr 1;4(4):e216040. DOI:10.1001/jamanetworkopen.2021.6040.
  • Effect of community-initiated kangaroo mother care on breastfeeding performance in low birthweight infants: A randomized clinical trial. Matern Child Nutr. 2022 Oct;18(4):e13419. DOI: 10.1111/mcn.13419.

Problem Addressed

Poor maternal and child nutrition leads to low birth weight and stunted growth.

What We Did

In a landmark study, we tested a package of health, nutrition, WaSH and psychosocial interventions delivered from preconception to early childhood.

What We Found

The integrated approach reduced low birth weight and stunting, with the greatest impact when interventions were given from preconception to childhood.

Impact

WINGS is being scaled up in some Indian states, offering a model for improving maternal and child health.

Real-World Impact

WINGS has the likelihood to transform how maternal and child health services are delivered, ensuring better outcomes for both mothers and their babies.

Investigators

Sunita Taneja, 
Ranadip Chowdhury, Neeta Dhabhai, 
Ravi Prakash Upadhyay, Sarmila Mazumder, Sitanshi Sharma, 
Harish Chellani, 
Nita Bhandari

Read More
  • Impact of an integrated nutrition, health, water sanitation and hygiene, psychosocial care and support intervention package delivered during the pre- and peri-conception period and/or during pregnancy and early childhood on linear growth of infants in the first two years of life, birth outcomes and nutritional status of mothers: study protocol of a factorial, individually randomized controlled trial in India. Trials 2020;21(1):127. DOI: 10.1186/s13063-020-4059-z.
  • Impact of a package of health, nutrition, psychosocial support, and WaSH interventions delivered during preconception, pregnancy, and early childhood periods on birth outcomes and on linear growth at 24 months of age: factorial, individually randomised controlled trial. BMJ 2022;379:e072046. DOI: 10.1136/bmj-2022-072046.
  • Burden, risk factors and outcomes associated with gestational diabetes in a population-based cohort of pregnant women from North India. BMC Pregnancy and Cehildbirth 2022;22(1):32. DOI: 10.1186/s12884-022-04389-5.
  • Breastfeeding practices based on the gestational age and weight at birth in the first six months of life in a population-based cohort of infants from North India. Frontiers in Pediatrics 2023;11:1127885. DOI: 10.3389/fped.2023.1127885.
  • Management of undernutrition during preconception and pregnancy in an urban setting in North India. Frontiers in public health 2024;12:1405247. DOI: 10.3389/fpubh.2024.1405247.
  • Child Neurodevelopment After Multidomain Interventions From Preconception Through Early Childhood: The WINGS Randomized Clinical Trial. Jama 2024;331(1):28-37. DOI: 10.1001/jama.2023.23727.

© World Health Organization 2022. Available under the Creative Commons Attribution-NonCommercialShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo)

Our systematic reviews and meta-analyses, including assessments of enteral supplementation of iron, zinc, vitamin D, vitamin A, calcium, phosphorus, and multiple micronutrients, have been pivotal in shaping global health policies. These reviews provided critical evidence that informed the World Health Organization’s updated Guidelines for the Care of Preterm or Low Birthweight Infants. By addressing gaps in knowledge regarding the role of micronutrients in preventing morbidity and mortality among preterm and low birth weight infants, our work supports evidence-based recommendations aimed at improving neonatal outcomes and promoting long-term health for this vulnerable population.

Lead Scientists

Ranadip Chowdhury, Bireshwar Sinha, Ravi Prakash Upadhyay, Tarun Choudhary, Barsha Gadapani Pathak, Rukman Manapurath, Temsunaro Rongsen-Chandola, Sarmila Mazumder, Sunita Taneja, Nita Bhandari

Read More
  • Enteral Vitamin D Supplementation in Preterm or Low Birth Weight Infants: A Systematic Review and Meta-analysis. Pediatrics. 2022 Aug 1;150(Suppl 1):e2022057092K. doi: 10.1542/peds.2022-057092K.
  • Enteral Zinc Supplementation in Preterm or Low Birth Weight Infants: A Systematic Review and Meta-analysis. Pediatrics. 2022 Aug 1;150(Suppl 1):e2022057092J. doi: 10.1542/peds.2022-057092J.
  • Enteral Iron Supplementation in Preterm or Low Birth Weight Infants: A Systematic Review and Meta-analysis. Pediatrics. 2022 Aug 1;150(Suppl 1):e2022057092I. doi: 10.1542/peds.2022-057092I.
  • Enteral Multiple Micronutrient Supplementation in Preterm and Low Birth Weight Infants: A Systematic Review and Meta-analysis. Pediatrics. 2022 Aug 1;150(Suppl 1):e2022057092N. doi: 10.1542/peds.2022-057092N.
  • Enteral Calcium or Phosphorus Supplementation in Preterm or Low Birth Weight Infants: a Systematic Review and Meta-analysis. Pediatrics. 2022 Aug 1;150(Suppl 1):e2022057092M. doi:10.1542/peds.2022-057092M.
  • Enteral Low-Dose Vitamin A Supplementation in Preterm or Low Birth Weight Infants to Prevent Morbidity and Mortality: a Systematic Review and Meta-analysis. Pediatrics. 2022 Aug 1;150(Suppl 1):e2022057092L. doi: 10.1542/peds.2022-057092L. WHO recommendations for care of the preterm or low birth weight infant. Geneva: World Health Organization; 2022 (https://iris.who.int/bitstream/handle/10665/363697/9789240058262-eng.pdf)